Monday, April 29, 2024

Uber, Lyft drivers to rally at Rhode Island State House

providence house

I really didn’t know if I was going to use again when I left, but they showed me I could be happy without drugs. Trauma-informed care is as essential to our mission as safe and dignified shelters and residences. The Sanctuary Model allows us to go beyond a simple exchange between “client” and “service provider” and create an emotionally safe space and supportive community. All of our programs employ the Sanctuary Model to weave our core values into our expanding work and growing team. The model actively involves each and every staff member and resident in creating and sustaining a supportive, therapeutic, trauma-informed environment. Our Transitional Shelter Program provides emergency housing, engaging residents for six to eight months.

Explore Our Network of Care

providence house

With the support of the Department of Housing and Urban Development (HUD) and the City of Shreveport, our goal is to rapidly get families housed and provide the necessary support to become self-sufficient. Providing a safe, private, and therapeutic environment to those suffering from addiction. Providence House is a drug and alcohol rehabilitation center in McKenzie County, North Dakota, serving both men and women. Receive a high level of support and clinical care during the day and go home at night. Whether you need attention for something minor or major, we’ve put in place additional protocols to make sure you feel comfortable and confident every time you seek care. If you are experiencing that kind of personal devastation or you know someone who is struggling in such a way – perhaps a family member or a friend – there is help at Providence House.

PROGRAM OVERVIEW

Our social services team works closely with each family to address concrete issues including making sure they’re connected to a primary care physician, securing a stable source of income and appropriate childcare. They help clients develop emotional management skills, strategies for making healthy choices in relationships, and finding opportunities for positive parent-child interactions. If there is a need for mental health services, our staff provides immediate support and makes referrals to mental health providers as indicated. Our Women’s Justice Program serves women experiencing homelessness who would otherwise be held at Rikers Island while awaiting trial.

Newport police announce road closures for Aquidneck Island Police Parade

Our Affordable Housing units are studio and two-bedroom apartments available to members of the community that meet the low income housing requirements. These residents are able to utilize the services of the staff, should they need. See a health care provider today at a convenient neighborhood urgent or ExpressCare clinic, now open with extended hours, 7 days a week. Our virtual visit services can treat and diagnose through online video and phone appointments. Workforce Development courses offer adults affordable, accessible job skills training in partnership with Bossier Parish Community College. Classes are held right here in downtown Shreveport on the Providence House campus.

Families displaced after a fire damages 2 homes in Providence - Turn to 10

Families displaced after a fire damages 2 homes in Providence.

Posted: Tue, 14 Nov 2023 08:00:00 GMT [source]

Safe In-Person & Virtual Appointments

Providence House operates a Type III, 4-STAR Child Development Center for its residents and the local community, providing children with the skills needed to be ready for kindergarten. The Adult HiSET Program is a way for adults who didn’t finish high school to earn a diploma and get on track for college or a career. The Prospect-Lefferts Gardens residence provides housing and supportive services for 16 women experiencing homelessness who would otherwise be held at Rikers Island while awaiting trial, most staying between nine - twelve months.

Weekly Workforce Development Skills: Goals

Our Permanent Supportive Housing is made up of four facilities employing a congregate housing model in Brooklyn, NY. These units are for families and single adults who have histories of chronic homelessness, serious mental illness (SMI) and/or Substance Use Disorder (SUD). As we recognize that many of our clients come to our residences with histories of trauma, Providence House utilizes a trauma-informed approach which allows us to provide a safe, supportive environment for our residents to heal. We offer practical and essential life skills training in order to progress independence and achieve daily goals. Through our case management and clinical services, we assist individuals and families in developing coping skills to help manage behaviors, family reunification and a host of other services.

You are assisted by Case Workers, Counselors, LAC's, an on-site Nurse, and staff, who all are constantly striving to make any adjustments needed to your program. You have Daily groups, which dive deeper into an understanding of our disease. The Staff takes everyone to meetings every day so you can start to build a sober fellowship, and first hand get to witness the experience, strength, and hope in those rooms, and that's when the miracles really begin.

Fire heavily damages Providence home - Turn to 10

Fire heavily damages Providence home.

Posted: Thu, 29 Feb 2024 08:00:00 GMT [source]

When I began my journey at Providence House, I was taught that the steps were a new way to live. With the guidance from God, staff, and everyone around me in Recovery, I was able to build a foundation. Whether it’s the spirit, love, or simply the fellowship, Providence House knows that no one is ever too lost to be found.

OUR MISSION

Additional courses and workshops are available through LifeShare Blood Center and other partners. It takes incredible courage to pursue recovery from alcohol and drug addiction. Our team understands first-hand the challenges that many of our patients experience. Our seamless approach to providing individualized care to each patient as they progress through the program is the cornerstone of our philosophy. Providence House offers a variety of treatment services from residential to low-intensity outpatient.

providence house

The Women’s Justice Program has been committed to serving women involved in the criminal justice system since its foundation in 1979 and continues to evolve to meet the changing needs of our clients. Today the program operates three residences in Brooklyn serving two different populations in congregate style facilities. We offer different levels of treatment to support those struggling with substance abuse and addiction. Our innovative therapy is based on best practices and practical applications of the time-proven principles contained in the 12 Steps of Recovery. It is our hope that while residents are with us they will increase their emotional management skills, confront and process the losses they’ve experienced, and move confidently ahead with greater of confidence and purpose.

Residents and staff practice recognizing the ways in which trauma affects us in our daily interactions and how sometimes additional layers of trauma come into our lives. Our two Bed-Stuy residences serve 27 women who were recently released from Rikers Island, providing a safe, empowering environment for families to reconnect. Your monthly gift can provide food, clothing, housing, education, and support that can forever transform the lives of families in need. Choose from intensive or low intensity outpatient treatment for substance abuse recovery. As a major pillar of society, the family truly deserves our best efforts to support and strengthen it.

10 Best Steakhouses in Las Vegas

steak house las vegas

It’s easy to be hypnotized by the 90-foot waterfall that turns into a screen playing Fantasia-esque shorts, but the fantastic steaks are even more impressive. Our go-to is the 16-ounce New York strip that has a nice peppery char, but the filet mignon and 18-ounce boneless ribeye are both always perfectly cooked. If SW wasn’t Hollywood enough, the steaks come from the ranch of the guy who created Yellowstone. While golfing, visitors can order chicken sandwiches, blackened mahi wraps, cheeseburgers, and steak tacos.

steak house las vegas

Golden Steer SteakhouseArrow

The Most Splurge-Worthy Las Vegas Restaurants - Eater Vegas

The Most Splurge-Worthy Las Vegas Restaurants.

Posted: Wed, 20 Mar 2024 07:00:00 GMT [source]

For the main event, you will find prime steaks such as a dry-aged bone-in ribeye, a Wagyu ribcage, and a shareable Porterhouse, as well as Japanese imports, like A5 Wagyu filet and F1 New York strip. Choose your pairing (the wine list focuses mostly on Californian labels) and your sides (like creamed spinach or roasted summer squash), and sink into the beauty of a Vegas classic. The feast begins with beautiful appetizers, such as maple-glazed pork belly or hamachi tartare, that will lead you to the steak section. You will find USDA prime cuts, such as dry-aged New York or ribeye, a Japanese beef burger, and an imposing 40-ounce American Wagyu Porterhouse. You can choose sauces such as red wine bordelaise and horseradish cream to accompany these delicacies, while side options include tempura onion rings, Kung Pao cauliflower, and wild mushrooms. Bid the evening (and Brad) farewell with a banana cream pie or a Valhrona chocolate soufflé.

BOOK A TABLE

The kitchen is helmed by chef Gina Marinelli, who brings an Italian touch to the menu — think summer corn ravioli, melon and prosciutto salad, and a lovely pasta selection. And if you're feeling extra fancy (this is still Vegas, after all), make sure you go for the caviar service, served with chive cream, potato latkes, preserved lemon yogurt, and perhaps even a sip of Louis XIII cognac. All of these are meant to go onto the grill that awaits at the center of your table. At Carversteak, anticipate a menu featuring dry-aged American steaks from artisan producers, Japanese-certified Wagyu steaks, and a playful variety of side dishes. Expect a reimagined steakhouse atmosphere with top-notch service and a commitment to quality ingredients.

Golden Steer

But we took the guesswork out of it and our picks will never disappoint. On any given night at Barry’s Downtown Prime, you could be eating alongside Drake or Mel Gibson. And sure, you could say that about a handful of Vegas restaurants, but what makes Barry’s stand out is their namesake 12-ounce rib cap. The thick steak is tender like a filet with the juiciness of a ribeye, a meal paired well with sides like the loaded baked potato or sweet and smooth creamed corn. For that one meat-abstaining friend, Barry’s has pretty good vegan options, including a salisbury “steak” made with red pepper and ratatouille-stuffed artichokes. SW feels like a steakhouse plucked out of Beverly Hills and placed along the Wynn’s Lake of Dreams, where you might be sitting next to a famous Swedish DJ or casino president.

Golden Steer Steakhouse In Las Vegas Is Expanding - 96.3 KKLZ

Golden Steer Steakhouse In Las Vegas Is Expanding.

Posted: Thu, 02 Nov 2023 07:00:00 GMT [source]

Relish the jam-packed sensations of the caviar, fried Blue Point oysters, Gordon Ramsay’s iconic Beef Wellington, or choose another authentic British dish - such as Shepherd’s Pie. Ramsay’s cuts of prime beef, which are aged to perfection by the culinary team are also available. Not to mention the host of French-influenced sides and desserts available.

SW Steakhouse

Swing by Hank’s for a stellar Happy Hour of half-off dirty martinis and bands covering Sublime at the piano bar. We like it for a steakhouse-lite experience of snacking on tiny tuna tacos and beef wellington bites dipped in beer cheese sauce. It’s a little more upscale than the typical Vegas gaming bars on the eastside, so there’s likely going to be a lot of the local Henderson crowd hanging out. If traffic makes you miss Happy Hour, you can still have an excellent meal by starting with the chunky crab cakes and wedge salad before slicing into the wet-aged petite filet mignon.

The bar serves cocktails like the birdie juice with gin, strawberry puree, basil, cucumbers, simple syrup, and Sprite — plus beer and wine. The ceiling of the chic steakhouse is splashed with the Union Jack Flag and towers over an alluring bar, lounge, and two-story dining area for guests to sit back and unwind in. For the discerning jetsetters, there’s also private dining rooms available or you could even dine at the chef’s table and witness the creation of all the delicious dishes. At Smith & Wollensky, anticipate top-quality steaks, an impressive wine list, and impeccable service. The ambiance is sophisticated, making it an ideal spot for both business and pleasure.

Best Steakhouses in Las Vegas

Jean Georges Steakhouse at Aria is a celebrated steakhouse in Las Vegas. You’ll find a selection of the finest cuts of meat, complemented by an impressive array of sides and sauces at Jean Georges Steakhouse. It’s located in the heart of the city at the ARIA Resort & Casino, a prime spot on the Las Vegas Strip. A night out in Vegas often starts at a steakhouse—and depending on how well you do at the tables, it might end there, too. That's why nearly every hotel has what it thinks is the best steakhouse in Las Vegas pushing Wagyu and USDA prime just off the casino floor. Yet with each restaurant bragging about its choice of meat (if you want to find a perfectly marbled cut the size of a small automobile, you are in the right place), choosing the right spot can cause a panic attack.

If you order one of the larger cuts, like a Wagyu tomahawk, they will be carved table-side, guaranteeing an even more enjoyable spectacle. At CUT, anticipate top-tier steaks and a carefully crafted wine list in a sophisticated setting. Set yourself up for a luxurious dining journey with an emphasis on quality and innovation.

As a guest, anticipate an array of mouthwatering dishes, including prime steaks, fresh seafood, and exquisite side dishes, all in a warm, intimate setting. Coupled with a richly curated selection of wines and cocktails, Bavette’s promises an unforgettable gastronomic journey without the cliched fanfare. Just take the martini cart rolling around during dinner service as an example. So when the investment bankers at the nearby table invite you for drinks at the bar, go along for the ride. Sure, this is a swanky party spot with great steaks, but where the restaurant shines is the seafood dishes.

At this dining venue, you can expect to indulge in prime cuts of beef that have been aged to perfection under the direction of Chef Ramsay and his team. Carversteak is a modern interpretation of the classic steakhouse, located at Resorts World in Las Vegas. You’ll find it conveniently situated within The Strip, one of the resort’s most vibrant areas. SW Steakhouse is a renowned American restaurant that specializes in premium steaks.

You can expect to savor prime steak, seafood, and lamb complemented by an array of fabulous sauces, sides, and meticulously selected wines. The restaurant provides an upscale dining setup with an impressive view of the famous Bellagio Fountains. The menu starts out with the Raw-shi bar, where you'll find oysters, sashimi, and a fabulous shellfish platter (which you can order chilled or with red miso butter).

The California-based WaBa Grill has opened a location of its rice bowl restaurant in Henderson. And as many as ten more restaurants may be on the horizon for Clark County. The chain makes bowls with grains, vegetables, and proteins like chicken, marinated ribeye steak, salmon, and jumbo shrimp. With that philosophy, you will find appetizers such as half a dozen oysters, a platter of salumi and cheese, or a meatball with tomato sauce and ricotta. The generous Bistecche & Costelette section features veal chops, lamb chops, bone-in ribeye, and a bistecca di mail (aka Berkshire pork chop), all of which can be served with Bérnaise or Andiamo sauce.

According to an update to that story, Clark County records indicate a building permit application for a “Vegas Country Music Restaurant” at 63 Las Vegas — the building near the Cosmopolitan, where Ocean Prime is located. But a representative for Wallen said that the musician was not opening a bar and restaurant at 63 or anywhere else in Vegas. You’ll find STK at the heart of The Cosmopolitan in Las Vegas, a modern twist on the traditional steakhouse. With its high-energy dining atmosphere and chic lounge, it’s more than just a place to eat.

Oaklyn Crumpler Obituary 1972 2023 Wilmington, DE

house of wright funeral home obituaries

As much as he leaned on me for support, I leaned on him just as much. We could talk to each other and not worry about the other person judging. I´m completely devastated that I will never be able to have another conversation with him. Rob meant the world to me, and he will forever be in my heart. My children loved him just as much as I did as well.

Memories and Condolences for Marlene Phipps

She joined the Golden K Kiwanis club with Frank and enjoyed the fellowship she found there. She and Frank were chosen Kiwanians of the year in 2015. May GOD comfort the Bright family during this difficult time. I lived on 27th Street and went to school with Gordon.

Local obituaries for Los Angeles County, California

house of wright funeral home obituaries

Tell us about a special moment you shared with Charles. Tortez is proud to show a first-time visitor a side of this landscape that some outsiders might miss. He thinks again about his people’s creation story and the plight of Mukat. It can be hard for locals in California’s desert, many of whom are Latinos working low-wage farm jobs, to feel as if the change they see around them takes their priorities into account, Ortiz says. She says the monument designation is important for other reasons. The valley is exploding not just with industry but with walled-off housing subdivisions, as well as a race track and other attractions.

Robert Wingfield Obituary

Before joining the paper in 2019, the Kentucky native spent nearly 25 years at the Seattle Times covering the Pacific Northwest. Follow him on Instagram @tyrone_california and Twitter @tyrone_beason. Villagers communicated with Mukat by sending coyotes into the hills to bring back his messages of wisdom and warning. Dashiell, 43, steps in close to enjoy a creosote bush’s telltale aroma of black tar and sand after a storm.

Oaklyn Cardell Crumpler Jr. was born on February 14, 1972 in Wilmington, Delaware to Oaklyn Crumpler Sr. and Tanya Crumpler. In addition to all his accolades he was offered many scholarships including one from West Point University. After high school he worked for Red Clay Consolidated School District as a custodian for many years before being promoted to Chief Custodian.

To offer your sympathy during this difficult time, you can now have memorial trees planted in a National Forest in memory of your loved one. LAfS, My family experienced several deaths in the past few years. We can always count on the professional services provided by JD with Los Angeles Funeral services.

Local obituaries for Montebello, California

Mary was a graduate of Lincoln Southeast High School and the University of Nebraska Kearney. Marlene was an avid reader and every time I saw her we had to discuss the latest book. She was cheerful and lovely and will be greatly missed. The laughter and joy of this world is certainly decreased. Talk about a shared experience you had with Gordon.

house of wright funeral home obituaries

Memorial Events for Mary Wright

In addition to brothers Buck Jones, Devonne, Stink, Gar, Mar, T-Y, Stevie, Derrick, Dennis, KB, Makim, Dupper, Henny,Man Man, Mel Mac, and Gundy.To send flowers to the family or plant a tree in memory of Oaklyn, please visit our floral store. Legacy's Linnea Crowther discusses how families talk about causes of death in the obituaries they write. Many individuals have not experienced the loss of a loved one and never have been tasked with making final arrangements.

With seeds that look like tiny cotton balls, the plant can produce clones of itself for hundreds or even thousands of years. As Tortez contemplates Chuckwalla’s richness, another member of the hiking group, Stephanie Dashiell, an environmental consultant who is manager of the national monument campaign, spots a thorny ocotillo growing high on a cliff. Tortez says pushing for Chuckwalla’s monument designation is hugely important to tribes, given that so many are vying for a stake in the region’s future. Evidence of these intersecting interests is clear in Chuckwalla, where power lines channeling electricity from solar farms farther east cut across the land. Talk about a shared experience you had with Jacqueline.

In announcing the legislation on the steps of the U.S. Capitol this month, Padilla said he was especially gratified that a coalition came together to craft the monument proposal — Indigenous leaders, community members, environmental groups, recreationists, renewable energy companies and local businesses. It would become the fifth-largest land-based national monument in the continental U.S. Tell us about a special moment you shared with Jacqueline.

William Butler Obituary - House of Wright Mortuary & Cremation Services - Wilmington - 2024 - Legacy.com

William Butler Obituary - House of Wright Mortuary & Cremation Services - Wilmington - 2024.

Posted: Tue, 23 Jan 2024 06:03:07 GMT [source]

Robert Aaron Wingfield was born on October 10, 1991, in Wilmington, DE to Shirley B. Meades and Buffel Wingfield. Find compassionate support for your end-of-life planning needs. Talk about a shared experience you had with Charles. Tyrone Beason is a reporter for the Los Angeles Times who writes about America through the lenses of race and culture. He previously covered the 2020 presidential election.

Donnie was very generous in sharing his produce with neighbors, friends, and family. Donnie loved spending weekends at Lake Lizzie and later at Prairie Lake. He loved to fish and spent many hours with Pat, Lonnie, and Jean in the boat.

They cremated their dead on wood funeral pyres for three days, to purify the bodies of the deceased and transition their souls back into the Earth. The Fort Yuma Quechan Indian Tribe wants Biden to use the same authority to establish 390,000 acres of their ancestral land in Imperial County as the Kw’tsán National Monument. Orange County returned 6 acres of land to the Acjachemen and Tongva people. Tribal leaders say it’s a small step in a movement to protect their heritage. Speaking later by phone, Ruiz touted the monument as important for helping California meet its conservation and climate change goals without encroaching on public lands already designated for other uses, such as green energy projects. Ruiz says his congressional district produces the most renewable energy on federal land in the U.S.

There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. RG302 was and still is a talent that God gave us and blessed us with to get us thru hard times and make the most of what we have.you are truly missed my brother. Talk about a shared experience you had with Robert. The most recent obituary and service information is available at the House of Wright Mortuary & Cremation Service - Wilmington website. Legacy invites you to offer condolences and share memories of Robert in the Guest Book below.

Jacqueline Harmon Obituary 1955 2023 Wilmington, DE

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Legacy is updated regularly throughout the day with submissions from newspapers, funeral homes, and direct from the community. View Long Beach obituaries on Legacy, the most timely and comprehensive collection of local obituaries for Long Beach, California, updated regularly throughout the day with submissions from newspapers, funeral homes, and direct from the community. View Lawndale obituaries on Legacy, the most timely and comprehensive collection of local obituaries for Lawndale, California, updated regularly throughout the day with submissions from newspapers, funeral homes, and direct from the community. View Montebello obituaries on Legacy, the most timely and comprehensive collection of local obituaries for Montebello, California, updated regularly throughout the day with submissions from newspapers, funeral homes, and direct from the community. According to the Cahuilla creation story, Tortez says, the people of this desert were born from a bolt of lightning that lit up the sky and flooded the empty land with life.

Memorial Events for Mary Wright

He is experienced and cares about you and your families needs. He treats your family member with dignity as well. Will be dedicated in honor of your loved one on the day of your choosing. We encourage you to contact the funeral home to verify time and location before attending services or visitation. View Los Angeles obituaries on Legacy, the most timely and comprehensive collection of local obituaries for Los Angeles, California, updated regularly throughout the day with submissions from newspapers, funeral homes, and direct from the community. View Los Angeles County obituaries on Legacy.com, the most timely and comprehensive collection of local obituaries for Los Angeles County, California.

The House of Wright Mortuary & Cremation Service

Some basic help and starters when you have to write a tribute to someone you love. Offering our deepest condolences during this difficult time. Talk about a shared experience you had with Oaklyn. Upcoming services provided by House of Wright Mortuary Inc. Barbara L. Walsh born November 12,1951 will be missed by family and friends.

Local obituaries for Los Angeles County, California

Israel has failed to achieve its two primary goals of the war, while the suffering of Palestinians erodes support even among its allies. Los Angeles Funeral Services was formed in 2006 to be a resource of providing dignified, memorable, and personalized funerals at a fair price and with personal attention unequaled to other mortuaries in Greater Los Angeles. We give every family options so they can make informed and reasonable choices. We welcome your phone call 24 hours a day, with absolutely no obligation. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution.

Native tribes are getting a slice of their land back — under the condition that they preserve it

I recently used their services with the passing of my mother in August. JD was so helpful and compassionate with our family. The prices and services were wonderful and made this difficult time for our family so stress-free. I can't stress how thankful I am to La Funeral Services. I loved him dearly, not only was he an amazing person but a true friend.

House of Wright Mortuary - Wilmington

Tell us about a special moment you shared with Diane. You were a friend first and last, and the world's best mother-in-law in between for almost 25 years, as well as an amazing grandmother to my sons. Your advice and good humor and support throughout the years were a testament to the wonderful person you were. I am comforted by the fact that you knew where you were going.

Talk about a shared experience you had with Diane. The most recent obituary and service information is available at the House of Wright Mortuary & Cremation Service - Smyrna website. Legacy invites you to offer condolences and share memories of Diane in the Guest Book below. In lieu of flowers, the family requests donations be made to Knute Nelson Home Health Care and Hospice, 1304 West Lincoln Avenue Suite B, Fergus Falls, MN, 56537. In the summer of 2023, he had over 30 tomato plants along with squash, cucumbers, and pumpkins.

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Local obituaries for Long Beach, California

I really appreciate everything they did for my mom and my family. They're not a map to follow, but simply a description of what people commonly feel. We'll help you find the right words to comfort your family member or loved one during this difficult time. They enjoyed taking friends and family with them in their boat.

Marlene Phipps Obituary

Memorials are suggested to the First Lutheran Church or the Kearney Area Animal Shelter. Condolences may be shared online at Services are entrusted to O'Brien Straatmann Redinger Funeral and Cremation Services. Mary met Frank in early 2004 when he had a hip replacement and was recuperating at his sister Judy's home a half block from Mary's house. Mary brought Cabela catalogs and other magazines for Frank to read and before long they fell in love.

I had the unfortunate task of planning a funeral service for my mom. JD and his team did an excellent job guiding me and my brothers through the process and making it as easy as possible. She was so compassionate and loving with me because I was having a difficult time.

She looked forward to visiting her church friends every Sunday. Mary served on many church committees; but enjoyed taking care of the flowers and was a mainstay helping to prepare communion. She delivered meals on wheels and was a long-time volunteer at the Kearney Area Animal Shelter.

With his love for children, he later changed positions and became a paraprofessional. His love for children led him to become a football coach where he coached at John Dickinson High School in addition to the Wilmington Titans and the City Raptors. Oak enjoyed spending time with his family, especially his children. His house was the go-to place to party, play cards, and eat.

Wendy McNeil Obituary - House of Wright Mortuary & Cremation Services - Smyrna - 2024 - Legacy.com

Wendy McNeil Obituary - House of Wright Mortuary & Cremation Services - Smyrna - 2024.

Posted: Tue, 19 Mar 2024 07:00:00 GMT [source]

His people have cherished and watched over this canyon in the eastern Coachella Valley for thousands of years. Now they are among the Indigenous Californians, conservationists and other nature lovers who want President Biden to designate 627,855 acres of desert where the canyon sits as the Chuckwalla National Monument. Mary was a faithful member of First Lutheran Church in Kearney.

Their favorite lakes were Harlan County, McConaughy, Davis Creek, Calamus, and Sherman. They also enjoyed fishing in Minnesota with Frank's brother, Max. Mary enjoyed watching the Huskers play football, baseball, and especially volleyball. Mary's happy place was working in her garden and raspberry patch. She had to buy extra shelves and another freezer to keep everything she had canned and frozen! Many neighbors benefited from her love of gardening.

Our Approach

design therapeutics

Xaira was co-founded by Dr. David Baker, Professor of Biochemistry and Director of the Institute for Protein Design at the University of Washington School of Medicine. The company now employs a group of researchers who developed the leading models for protein and antibody design, RFdiffusion and RFantibody, while in Dr. Baker’s lab. Xaira’s broader team will advance these models and develop new methods that can connect the world of biological targets and engineered molecules to the human experience of disease. DT-216 Phase 1 MAD Trial DesignThe Phase 1 MAD clinical trial is a randomized, double-blind, placebo-controlled study designed to evaluate multiple ascending doses of DT-216 administered intravenously in adult patients with FA. The primary and secondary study objectives were to evaluate safety and tolerability, and pharmacokinetics (PK) of three weekly doses of DT-216 in FA patients.

Ex­clu­sive: In $1B+ bet on AI, bio­phar­ma heavy­weights back new start­up to up­end drug R&D

Discovery efforts for multiple other small molecule genomic medicines are also underway. We believe our experiences with GeneTAC™ molecules allow us to more rapidly design GeneTAC™ molecules for additional indications. Our DM1 GeneTAC™ small molecules were shown to reduce observable CUG nuclear foci and correct splicing defects in DM1 patient-derived myotubes. We are working toward selection of a development candidate in anticipation of a future IND submission. Fuchs Endothelial Corneal Dystrophy (FECD) is a genetic eye disease characterized by bilateral degeneration of corneal endothelial cells (CECs) and progressive loss of vision. Typically, the disease manifests after age 40 and can be detected through routine eye exams.

Small Molecule

Design believes these data support use of the muscle FXN mRNA assay as a sensitive indicator of clinical activity in FA, with the ability to discriminate clinically meaningful changes in endogenous FXN mRNA. Dr. Jeffries brings over twenty years of experience in biopharma with extensive experience in strategy and R&D. Prior to Design, Dr. Jeffries led projects to develop R&D and therapeutic strategies for biopharma at the Boston Consulting Group. He was instrumental in pioneering miniPCR, which performed the first PCR on the international space station.

Design Therapeutics Highlights Upcoming Milestones and Reports Second Quarter 2022 Financial Results

Design Therapeutics divulges new compounds for treatment of Huntington's disease - BioWorld Online

Design Therapeutics divulges new compounds for treatment of Huntington's disease.

Posted: Tue, 24 Oct 2023 07:00:00 GMT [source]

These foci inhibit the ability of MBNL1 to process pre-mRNAs, which when mis-spliced disrupt muscle development and function that is characteristic of DM1. Design Therapeutics, Inc a biopharmaceutical company, researches, designs, develops, and commercializes small molecule therapeutic drugs for the treatment of genetic diseases in the United States. The company utilizes its GeneTAC platform to design and develop therapeutic candidates for inherited diseases caused by nucleotide repeat expansion. As a result, the DM1 GeneTAC™ molecules are designed to prevent the formation of the CUG hairpin structures that trap splicing proteins and produce nuclear foci. As with our other programs, the DM1 program is designed to address the underlying cause of the disease and benefit from the favorable development advantages of small molecules. Pratik Shah, Ph.D., is co-founder, president, chief executive officer and chairperson of Design Therapeutics.

There are currently no approved therapies that can reverse or slow down the course of HD. Friedreich ataxia (FA) is a devastating monogenic, autosomal recessive progressive disease caused by low levels of endogenous Frataxin (FXN) due to abnormally expanded GAA triplet repeat expansions in the first intron of the FXN gene. The disease is characterized by spinocerebellar ataxia, dysarthria, pyramidal weakness, deep sensory loss, hypertrophic cardiomyopathy, skeletal abnormalities and diabetes mellitus. Clinical onset occurs most often around puberty, leading to severe disability by early adulthood, with substantial functional loss, wheelchair dependence and loss of quality of life.

Myotonic Dystrophy Program

design therapeutics

Xaira’s internal platforms incorporate leading technologies and personnel which were spun out into Xaira at inception from Illumina’s long-standing functional genomics R&D effort. The company has also integrated a leading proteomics group from Interline Therapeutics. Rodney Lappe, Ph.D., has had a distinguished career as a biopharmaceutical scientist and executive.

Our novel small molecule therapeutic candidates are GeneTAC™ (Gene Targeted Chimera) molecules that target the underlying cause of inherited genetic diseases. Observational Biomarker Study in Friedreich AtaxiaIn parallel to the Phase 1 MAD study, Design conducted an observational study to evaluate FA biomarker assays in blood and skeletal muscle from individuals with FA, FA carriers and normal healthy volunteer controls for use in DT-216 interventional studies. The company developed procedures and methods to measure both FXN mRNA and FXN protein in muscle. Initial data from the observational study is based upon a data cutoff of August 7, 2023. Skeletal muscle biopsies were obtained from study participants at two visits several days apart to measure FXN mRNA and protein levels and characterize inter-and intra-individual variability.

DT-216 muscle exposure in FA patients was lower than projected from animal studies but was sufficient to result in significant PD response in skeletal muscle. Initial data from the Phase 1 MAD trial is based upon a data cutoff of August 7, 2023. The study is fully enrolled but currently ongoing, with blinded PK and pharmacodynamic (PD) data available in the full 100 and 200mg dose cohorts and 11 of 14 participants in the 300mg dose cohort. Ms. Burgess brings more than 25 years of experience in financial reporting, technical accounting, debt and equity financings, and financial planning and management for public and private biotechnology companies.

Program is the Product of a Research Collaboration between Biolojic Design and Nektar entered in 2021

Design modifications offer promise for safer and more effective mRNA therapeutics - News-Medical.Net

Design modifications offer promise for safer and more effective mRNA therapeutics.

Posted: Wed, 06 Dec 2023 08:00:00 GMT [source]

He became involved in Auspex as an investor in 2007 and served as its chairperson until he took over as its chief executive officer in 2013, after which he took the company public and oversaw its growth until its acquisition by Teva Pharmaceuticals for $3.5 billion in 2015. Before that, Dr. Shah was a partner in the healthcare venture capital firm Thomas, McNerney & Partners for nearly a decade, and prior to that, he co-founded two biotechnology companies and was also a consultant at McKinsey & Company in San Francisco. Dr. Shah obtained his Ph.D. in biochemistry and molecular biology as well as his MBA in finance from the University of Chicago. Individuals with nucleotide repeat expansion diseases are born with abnormally expanded stretches of specific nucleotide sequences, often with hundreds to thousands of repeats present in the mutant gene.

DM1 is caused by a mutation in the DMPK gene and is estimated to have a genetic prevalence of 1 in 2,300–8,000 people, affecting more than 70,000 people in the United States and more than 90,000 people in Europe. Each of these programs has the potential to generate blockbuster products with first-in-class or best-in-class profiles. Our proprietary GeneTAC™ platform offers significant potential advantages over other modalities. When systemically administered, GeneTAC™ molecules can distribute widely to reach target cells, overcoming a central challenge for traditional genomic medicines.

The favorable systemic safety profile and FXN response support continued development of DT-216. However, the company has elected to complete dose escalation in this Phase 1 study at the 300mg cohort due to concern for potential worsening of injection site thrombophlebitis at higher doses with multiple administration. Design has shifted focus to developing DT-216 with an improved formulation to enable higher exposures and chronic intravenous administration for treatment of FA. Nonclinical studies showed that the injection site reactions were attributable to the excipients in the current DT-216 formulation, and that improving the formulation composition could enable higher doses and chronic administration.

She currently serves on the grant funding committee for UC Davis and as a charter member for TiE, a non-profit global network of entrepreneurs and venture capitalists. Ms. Prasad earned her bachelor’s degree in business administration at the University of California, Berkeley and her M.B.A. from the Kellogg School of Management at Northwestern University with emphasis in finance and health industry management. Xaira’s advances in biological machine learning are underpinned by the company’s ability to generate, integrate, and learn from vast multidimensional data sets that comprehensively characterize disease-relevant biology at all scales, from molecules to people.

"The board looks forward to supporting the team in building a transformative company under the visionary leadership of Marc Tessier-Lavigne," said director Scott Gottlieb, former Food and Drug Administration commissioner and current NEA partner. "Xaira promises to be a magnet for the best talent in AI and drug development," added director Kaye Foster, Senior Advisor, The Boston Consulting Group and former SVP, Global Human Resources, Onyx Pharmaceuticals. Under the 2021 research agreement, Nektar has tested antibodies computationally designed by Biolojic Design to precisely agonize the TNFR2 receptor. Nucleotide repeat expansion mutations have been identified as the underlying cause of more than 40 debilitating, and typically rare, degenerative genetic diseases that collectively impact millions of people worldwide.

Dr. Xu joined Roche from McKinsey US and worked in biotech R&D earlier in her career. Dr. Xu currently serves on the boards of Walking Fish Therapeutics, Zidan Medical, HBM Healthcare Investments AG and Therorna Inc. She was also previously a board member of ARMO BioSciences (ARMO), NextCure (NXTC), Centrexion Therapeutics and Tempest Therapeutics. We are advancing a pipeline of novel candidates with an initial focus on monogenic repeat expansion disorders with urgent medical need, including Friedreich ataxia, Fuchs endothelial corneal dystrophy, Huntington’s disease and myotonic dystrophy. We are a biopharmaceutical company advancing novel, small molecule therapeutic candidates designed to bring functional cures to serious genetic diseases with long-standing unmet need.

design therapeutics

Finally, Jump Financial LLC boosted its position in shares of Design Therapeutics by 284.7% during the third quarter. Jump Financial LLC now owns 46,700 shares of the company's stock worth $110,000 after acquiring an additional 34,561 shares during the last quarter. Pharmacokinetics Plasma PK data were available in participants at 100mg, 200mg, and 300mg DT-216 doses. The average DT-216 concentration in muscle was approximately 8-10nM two days after the third weekly dose and approximately 1nM seven days after the third weekly dose in both the 200mg and 300mg cohorts.

Nucleotide repeat expansions are pathologic when they either impair transcription of the mutated gene (e.g., in Friedreich ataxia) or lead to formation of a pathogenic mRNA or mutant protein (e.g., Fuchs endothelial corneal dystrophy or Huntington disease). A higher number of excess repeats can lead to more severe, and sometimes a more rapidly progressive, form of disease. Over 70% of FECD cases are caused by cytosine-thymine-guanine (CTG) nucleotide repeat expansions in the TCF4 gene, which is transcribed into pathogenic TCF4 RNA that forms nuclear foci and sequesters splicing proteins, leading to transcript mis-splicing (spliceopathy) and CEC death. CECs harbor the longest known TCF4 repeat expansions in the body, potentially explaining why the cornea is the only affected tissue.

Sunday, April 28, 2024

Sydney auctions: Luxurious Wahroonga house with a bedroom for the dog sells for $9 1 million

house bed

In our most recent survey, we collected more than 100,000 data points to analyze, and we used them to find top-performing bedroom furniture brands with excellent customer service and quality. In addition to researching brands, materials and design features, we also had our testers try some of the frames in their own homes to get real-user feedback. Jack Byram is a commerce writer that is no stranger to writing about all things sleep-related. Since Thuma’s founding in 2018, the company has sought to make products that are environmentally friendly and designed with intention. The brand is looking to crack down on the waste that results from constructing wooden bed frames, working with One Tree Planted to plant one tree for every bed made.

Zinus Taylor Platform Bed Frame

We've tested several bed frames from Zinus, including a stylish farmhouse frame and a modern wooden option, and we're always impressed by the quality for the low price tag. While a comfy and supportive mattress is the most important purchase for your bed, other elements like your sheets and your duvet cover can impact your bedroom's aesthetic. Choosing the right bed frame is the final key to creating a cohesive space. Plus, your bed frame can even help maintain the longevity of your mattress. Our roundup, with the exception of the Avocado trundle frame, more or less hover in a humble price range of $200 to $600.

Montessori Toddler Bed 35" x 68" plan how to build / Full plan PDF / Instruction for Wooden Floor Bed for Kids Bedroom

The mattress base is approximately 12 inches off the floor and a small, one-step ladder takes your child up into the bed. Once there, they are protected by rails at the back of the bed and at both ends, while the walls at the front prevent them from rolling out in the middle of the night. When it is put together, the underside of the bed is six inches above the floor.

House Bed Frame Twin Made in US optional slats and legs

The head and foot of the base lift and lower with the press of a button, which is great for someone with chronic pain, snorers or those who just want a comfy way to sit up in bed while watching TV or reading. Our testers noted that while the bed frame is a breeze to build (one tester even put it together on her own), the pieces are large and heavy. And while the brand offers a generous 100-day trial period, the original boxes are needed for returns. But while it may only be one bed, it is important to note that there are a few chances to customize it. Three distinct color options (walnut, natural, and espresso) as well as the choice between a pillow board or headboard ensures that you’re getting something tailored to your own style and needs. At the time of publish, there are 868 options for beds and headboards on Ikea’s website—chances are, you’ll be sure to find something that completes your space.

SLATTUM Upholstered bed frame, Queen

house bed

While it’s marketed for children, the longevity of the frame makes it an excellent option for a guest room, or those who want to reuse the frame for multiple kids over the years. The pull-out trundle portion of the frame is a large drawer in both appearance and function. Use it to store the second twin mattress and pull out as needed, or as a more permanent home for linens, toys, and clothes. It's important to note that the shipping cost can be several hundred dollars and depends on where you live, but it comes with white glove delivery, so it's placed in your room of choice and fully assembled. The Hampton Collection has matching nightstands, dressers, desks and storage available too, so all of your bedroom furniture can coordinate. The brand recommends screwing the headboard into the wall with the included fasteners for some added stability.

We also surveyed our group of GH panelists on furniture they personally own, including their mattresses and sofas, to gather feedback on furniture brands and their customer service. We sent some of the bed frames t0 our consumer testers who tried the beds out in their own homes before sharing their thoughts on overall quality, assembly, delivery and more. The Marco Island Captain’s Bed is a sleek-looking, minimalistic frame, perfect for adding beds to your house to accommodate visiting friends and family, especially those with children and young adults. Reviewers said the wooden frame felt sturdy and high-quality, and was fairly easy to put together (although if you’re less handy, you may want to recruit help).

However, because of the way the bed is assembled, you can set the base higher or lower than the standard height. This allows you to put the bed closer to the floor or high enough to accommodate under-bed storage. The bed is made from 100 percent solid poplar, grown and harvested locally in Ozark, Missouri. That’s the same location as the beds are made, and it comes with everything you need for assembly.

With twin, full, queen, and king size options, you’re sure to get what you need. Plus, a queen-size version of the bed is priced at just under $150, making it one of the more affordable options out there. You can also choose to go without slats and have your child’s mattress on the floor, use a box spring within the frame, or add slats to raise the mattress two inches from floor level. If you like the look of house beds but you’re not a fan of the idea of your child sleeping at floor level, there is this option from Purveyor 15.

Rooted in a low-waste philosophy since 2013, Floyd founders Kyle Hoff and Alex O’Dell have built the brand from a single product into a wide line of items that are as sleek as they are functional. Today, Floyd features a robust set of products for the bedroom, living room, storage, and outdoors that you can order from the company’s website. If you are going for a house bed with legs or one of the raised versions, your child must be old enough and coordinated enough to climb in and out of the bed safely. The majority of house beds are made from wood, but you will see the occasional metal option.

Avocado doesn't allow returns for its furniture, so it is a big commitment, but we've regularly been impressed by the brand's products, including its bedding and mattresses. For a more sustainable, organic mattress alternative to pair with your new bed frame, we recommend the brand's Green Mattress, one of our favorite organic mattresses — backed by years of testing. There are three wood finishes to choose from that online reviewers describe as "beautiful," and there's an entire collection of furniture to match including dressers, bookcases and media consoles. Online reviewers also spoke highly of the quality of the mahogany wood, sharing that it's well-made and feels sturdy.

The Hancock Is the Party House of Bed-Stuy - Curbed

The Hancock Is the Party House of Bed-Stuy.

Posted: Mon, 04 Dec 2023 08:00:00 GMT [source]

That means even most adults could sleep on either bed if there was a need. The bed comes with everything you need for assembly, including all hardware and a hex key. However, some owners said they found it easier to put the bed together with a power drill. Either one of the cross beams on the longer side of the bed can be removed without compromising the structural integrity of the frame. This enables an adult to play with their child without the risk of banging their head.

10 Best House Beds of 2024

house bed

The bed is available in three timeless neutrals (gray, espresso and white), so you don’t have to worry about overhauling your guest room’s existing color scheme. The bed is available in either twin or full size, which, thanks to a sale, was at publication time the cheaper option among the two. Self-assembly is required, but online reviewers say building the bed frame is an easy enough task for one person, and the Velcro-like wooden slats make assembling the base a breeze. Trundles are a popular choice of furnishing for those who are low on floor space. Consequently, twin-size trundle beds that require two twin or twin XL mattresses are the most commonly seen frame models. Be sure to grab your room measurements before you order any frame to ensure you order a fitting piece for the space.

Most Popular

The bed frame is available in two wood finishes and three fabrics with two leg types (straight or tapered) and an optional headboard. With 15 bed frame options, Article has less of a selection than many other brands on our list, but each of the 15 choices is great in its own regard. It features concealed joinery for a clean finish and is built from solid and veneered American black walnut or American white oak for a finish that is both gorgeous and durable. Once you’ve decided on the primary style of bed that suits your needs, consider whether you’d like a bed frame with built-in storage drawers.

C. W. Worth House in Wilmington voted #1 in USA TODAY readers’ choice contest - WECT

C. W. Worth House in Wilmington voted #1 in USA TODAY readers’ choice contest.

Posted: Mon, 21 Aug 2023 07:00:00 GMT [source]

BRIMNES Bed frame with storage & headboard, Queen

If your child already has a larger bed, or will soon be too big for their toddler bed, a twin crib mattress might be your best option. If your child has skin sensitivities, an organic crib mattress may be a good option. These beds have a frame of poles or beams in the shape of a house set around the spot where the mattress sits. The majority of house beds, although not all, have the mattress at or near floor level. The roof still has crossbars, so the structure is just as stable as other house bed frames.

House Bed Frame Twin Made in US optional slats and legs

According to the brand, a box spring isn't necessary because the supportive wooden slats are between 3 and 3.4 inches apart. If you prefer an even simpler look, the frame is available without a headboard, and it comes in black or white metal. Much like clothing, there are many different materials that bed frames can be made out of. From metal to wood, if your bedroom has a particular vibe, you can certainly find a plethora of beds to accommodate it. But that being said, the prices don’t seem to be deal breakers because customers love the bed frames for their quality and long-lasting builds. One drawback with this bed frame, as well as others at Pottery Barn, is the price tag.

The velvet upholstered bed frame is available in fashionable colors like green, pink and navy, along with basic black and white. The wingback design extends above your mattress and is padded for added comfort when it's time to lean back and relax in bed. If you are looking for a metal house bed frame rather than a wooden one, Merax produces an affordable yet sturdy option. Having said that, hybrid mattresses are not the best go-to for a trundle. The added height from the coils often makes them too tall to slip under the frame, and their heft may have them exceeding the average weight limit for the top mattress.

If you live in a smaller space and bump into your bed during the night, we would recommend something with more padding such as Pottery Barn’s Camino Upholstered Platform Bed. One drawback with this bed, however, is that it requires a box spring, which is another added inconvenience to have to purchase if you don’t have one. However, if you are already a box spring owner, then enjoy the bed that boasts a 4.7-stars-out-of-5 rating. If you’ve ever decorated a new space, odds are you’ve shopped at or purchased something from Ikea. And with good reason, because the Swedish furniture powerhouse has been making household goods since 1943.

The density of this solid wood frame also means durability, so this is definitely a frame for the long haul. The Novogratz Her Majesty Upholstered Daybed and Trundle is a hybrid daybed and trundle, hence the name. Daybed versus trundle may seem synonymous, but most of the time, the name does signify a difference in the design.

Seamless outdoor living space was added as well as a two-level area that could be rented out separately or used for guests. Alongside the glamour of the infinity pool there is even a chicken coop and vegetable garden for sustainable living. By clicking on the product links in this article, Mattress Advisor may receive a commission fee at no cost to you, the reader. Good Housekeeping participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Emma Seymour (she/her) is a senior product analyst at the Good Housekeeping Institute's Textiles, Paper and Apparel Lab, where she has led testing for luggage, pillows, towels, tampons and more since 2018. The main bed has a weight limit of 400 pounds while the trundle has a limit of 275 pounds.

The roof is a polyester sheet with silk-printed stripes and can be removed completely if you want the bed to be more open. Alternatively, you or your child can roll down the door and/or window panels and keep out annoying siblings. The maker is extremely helpful if you have any questions either before or after purchase.

Much more than just a basic frame, this house bed has a full roof, side bed rails, and a panel at the front with windows on either side of the doorway. The outside of the panels have been deliberately left to look a little rough, but they are sealed and painted so there’s no risk of your child getting splinters. Alternatively, you can use the frame as a toddler bed and a separate outdoor playhouse. Finally, you can convert to a full-size bed, although without the bed house frame. If you want the benefits of a house bed that sits on the floor, but you aren’t comfortable putting your baby into this type of bed, Storkcraft has the answer.

While exorbitantly more expensive bed frames are out there, you’ll be hard pressed to find many other options under $200. Consider what you’ll sacrifice if you go seeking from retailers like Wayfair a lower-end trundle frame — namely, durability, and potentially comfort as well. For this article, she analyzed thousands of data points from GHI survey panelists, who shared information about their own mattresses and bed frames.

In the case of a daybed, it’s geared to be a functional couch and bed, and Her Majesty offers just that. The upholstered frame sits on attractive wooden legs (a feature often missing from an IKEA daybed, for instance), giving a mid-century modern couch look that could double as a sofa bed. When you’re hosting a VIP house guest, it’s time to roll out the red carpet.

house bed

Some house beds have bumpers and railings made to look like a picket fence, while others have partial walls, roofs, or windows. If you want to go for luxury, you can opt for a double, queen, or even a king-size house bed. Rather than the standard bed frame with four equal uprights, this house bed has posts that are taller at one end of the bed than the other. This creates a roof that is not symmetrical and is intentionally lopsided. However they have come across your radar, you may be wondering what they are, if there is any benefit to them, and how to select the best house beds.

5 Best Toddler Floor Beds of 2024 - Best Montessori Floor Beds - What To Expect

5 Best Toddler Floor Beds of 2024 - Best Montessori Floor Beds.

Posted: Tue, 19 Mar 2024 07:00:00 GMT [source]

The first CB2 was launched in 2000 in Chicago, and since then it has grown to feature 19 total storefronts across the United States. If your house is short on storage, finding a bed with storage might be a big deal. To help you choose the best house bed for your child, we’ve put together some guidelines for you to keep in mind while shopping. Part house bed, part cabin frame, party tent, this bed from Little Seeds is as much a place to play as it is a place to sleep. It takes a standard full-size mattress so there is plenty of room for stuffed toys, pillows, or anything else your little one likes to snuggle up with at night.

We like the Mainstays 14" Heavy Duty Steel Slat Queen Platform Bed Frame for its super reasonable price ($100 for a queen) and its durable materials to make sure it lasts you quite some time. Article has been focused on creating stylish, long-lasting furniture since 2013. In that time the company has established itself as a powerhouse in making contemporary, modern, and midcentury furniture. In particular, we really like one of its bestsellers, the Hemming Bed, a sleek, modern, and minimalist product. One drawback that some customers have found with their Floyd Home bed frame is that the expansion kit is a bit expensive.

An excellent solution to make a small space more hospitable is a trundle bed. Trundle beds house a second bed underneath that can be tucked away or rolled out at your leisure. Because the second mattress is stowed under when not being slept upon, the frame essentially houses two spots to sleep, but with the square footage footprint of a single. Plus, trundle beds aren’t just great for tiny homes and apartment dwellers. The multi-faceted beds also make an excellent kids’ room feature when hosting sleepovers. For a luxurious look, velvet bed frames are majorly on-trend, and this one is on sale for under $225.

Our Programs

design therapeutics

Design is pioneering the field of small molecule genomic medicine, which holds the potential to safely and effectively deliver meaningful change to patients in need. Dr. William has served as Managing Partner and Chief Investment Officer of Logos Capital since its founding in 2019. Prior to founding Logos, Dr. Williams served as an investment professional at Farallon Capital Management.

Faculty

The platform is also being built to transform every laboratory and clinical experiment into a vehicle for rich data generation. The product development process itself fuels the development of improved AI models and biological foundation models. The structures of GeneTAC™ molecules enable them to bind and act specifically at the site of the disease-causing nucleotide repeat expansion. They target the mutant gene and modulate the cell’s native transcriptional machinery, selectively halting or resuming the expression of specific genes and in turn blocking pathogenic mRNA or protein production and restoring functional protein production. FA is a multisystem degenerative disease caused by a GAA nucleotide repeat expansion in the FXN gene that impairs transcription and reduces FXN mRNA.

The GeneTAC™ Molecule: A New Class

About Design TherapeuticsDesign Therapeutics is a clinical-stage biotechnology company developing a new class of therapies based on its platform of GeneTAC™ gene targeted chimera small molecules. The company’s GeneTAC™ molecules are designed to either dial up or dial down the expression of a specific disease-causing gene to address the underlying cause of disease. In addition to its lead GeneTAC™ small molecule, DT-216, in development for patients with Friedreich ataxia, the company is advancing programs in Fuchs endothelial corneal dystrophy and myotonic dystrophy type-1. Discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions are also underway, including for fragile X syndrome, spinocerebellar ataxias, Huntington disease, spinobulbar muscular atrophy, and C9orf72-amyotrophic lateral sclerosis/frontotemporal dementia. Design’s lead program is focused on the treatment of Friedreich ataxia, followed by a program in myotonic dystrophy type-1 and discovery efforts for multiple other serious degenerative disorders caused by nucleotide repeat expansions. About Design TherapeuticsDesign Therapeutics is a biotechnology company developing a new class of therapies based on its platform of GeneTAC™ gene targeted chimera small molecules.

Board of Directors

Most recently, Dr. Lappe served as executive chairman of the board of directors for Mirati Therapeutics (MRTX), a role he had served at until he resigned in February 2019, after becoming a member of the board in June 2012 and chairman of the board in July 2013. Previously, Dr. Lappe was group senior vice president, Pfizer Worldwide Research and Development and chief scientific officer for CovX in San Diego. Dr. Lappe has also served as vice president for cardiovascular and metabolic diseases at Pharmacia where he was also site leader for Pharmacia in St. Louis. Prior to joining Pharmacia, he held positions with Wyeth, Rorer Central Research, CIBA Geigy and Searle Pharmaceuticals. "In my previous roles, I witnessed an earlier generation of technologies fundamentally change drug discovery, delivering new medicines that alleviate the burden of disease for many patients," said Dr. Marc Tessier-Lavigne, CEO.

Prior to that, Dr. Jeffries established and led the informatics group at Kalypsys. Dr. Jeffries completed his Ph.D. at the University of Cambridge in epigenetics as an NIH-Cambridge scholar. Sarepta’s gene therapy engine provides a framework for creating a steady stream of new therapies for devastating diseases, such as limb-girdle muscular dystrophies.

Ex­clu­sive: In $1B+ bet on AI, bio­phar­ma heavy­weights back new start­up to up­end drug R&D

Currently, there are no approved disease modifying therapeutic options that address the cause of nucleotide repeat expansion diseases. Through our proprietary GeneTAC™ approach, we can design and develop therapeutic candidates that dial gene expression up or down without requiring gene editing. HD is caused by a mutation that leads to an increased number of CAG triplet repeats in Exon 1 of the Huntingtin (HTT) gene. Expression of mutant HTT (mtHTT) negatively affects many cellular functions, leading to neuronal death and brain atrophy as symptoms manifest. Wild-type HTT (wtHTT) is thought to be important for normal neuronal function in the adult central nervous system (CNS). It is reported to be involved in axonal transport, synaptic function and cell survival.

Exploring the Potential of Gene Therapies for Limb-girdle Muscular Dystrophies

design therapeutics

Design has since shown that an improved formulation had favorable injection site tolerability following multiple intravenous administrations and enabled dosing to increase tissue exposure. Our FECD program leverages our expertise in designing GeneTAC™ small molecules that address the underlying cause of the disease. FECD GeneTAC™ molecules have shown to markedly reduce nuclear foci and improve spliceopathy in FECD CEC cultures derived from donors who underwent corneal transplant.In December 2022, DT-168 was declared a drug candidate for FECD. DT-168 is a GeneTAC™ small molecule designed to target the CTG repeats in the TCF4 gene and selectively block transcription of the expansion-containing allele. He has deep experience developing innovative therapies across multiple diseases and therapeutic modalities through all phases of drug development. Prior to joining Design, Dr. Kim was Chief Medical Officer of Avidity Biosciences.

Design Therapeutics Company Profile

Harnessing synthetic biology for advancing RNA therapeutics and vaccine design npj Systems Biology and Applications - Nature.com

Harnessing synthetic biology for advancing RNA therapeutics and vaccine design npj Systems Biology and Applications.

Posted: Thu, 30 Nov 2023 08:00:00 GMT [source]

Nisa Investment Advisors LLC increased its stake in shares of Design Therapeutics by 38,433.3% in the fourth quarter. Nisa Investment Advisors LLC now owns 11,560 shares of the company's stock worth $31,000 after purchasing an additional 11,530 shares in the last quarter. SG Americas Securities LLC purchased a new stake in shares of Design Therapeutics in the third quarter worth $47,000. Corton Capital Inc. increased its stake in shares of Design Therapeutics by 56.6% in the third quarter.

design therapeutics

The variability of results observed with this current method substantially limited the utility of FXN protein measurements to assess DT-216 pharmacology. Myotonic dystrophy (DM1) is a monogenic, autosomal dominant, progressive neuromuscular disease that affects skeletal muscle, heart, brain and other organs. The cardinal features include muscle weakness, myotonia (slow muscle relaxation) and early cataracts. In addition, affected individuals often experience cardiac arrhythmias and changes in neuropsychological function.

There is currently no effective therapeutic intervention that addresses the root cause of the disease. Corneal transplantation, including various modalities of keratoplasty, is the only treatment option to correct advanced FECD. In August 2023, we reported data from the MAD Phase 1 clinical trial showing that DT-216 was generally well-tolerated and exhibited the ability to overcome the FXN transcription impairment that causes FA. We have developed a new drug product candidate, DT-216P2, for patients with FA that demonstrated an improved pharmacokinetic profile and a favorable injection site safety profile in nonclinical studies. Xaira is building significant AI research capabilities spanning fundamental computational methods development and their application to biological discovery, the design of drug-like matter, and clinical development.

Prior to Design, Ms. Burgess served as the senior vice president of finance at Otonomy, Inc., Corporate Controller at Apricus Biosciences, and a consultant to several other biopharmaceutical companies. Ms. Burgess is a licensed CPA and completed her MBA at San Diego State University. This collective knowledge and expertise serve as the engine for our innovative approach and make us uniquely equipped to harness the power of our GeneTAC™ small molecules for the treatment of genetic disease. DT-216 Program Next StepsThe initial results from Design’s Phase 1 multiple ascending dose trial underscore the promise of DT-216 as a potential disease-modifying treatment for FA. FXN protein measurements in skeletal muscle had substantial overlap between FA patients and carriers and showed high intra-individual variability. More than half of FA patients had 25% or more variation in FXN protein levels between visits, with intra-individual coefficient of variation of 69%.

GeneTAC™ molecules are also designed to work with the natural genome without altering a patient’s DNA. Dr. Louise Rodino-Klapac discusses the science of limb-girdle muscular dystrophies (LGMDs) and how our gene therapy engine will help engineer potential therapies for this group of inherited neuromuscular diseases. Royal Bank of Canada restated a "sector perform" rating and set a $4.00 target price on shares of Design Therapeutics in a research report on Wednesday, March 20th. Wedbush restated a "neutral" rating and set a $5.00 target price on shares of Design Therapeutics in a research report on Wednesday, March 20th. Seven analysts have rated the stock with a hold rating, According to MarketBeat.com, the stock currently has a consensus rating of "Hold" and a consensus price target of $5.50.

Affected individuals have reduced life expectancy, with many premature deaths caused by complications of cardiomyopathy at about the end of the fourth decade of life. The estimated prevalence of FA is 1 in 40,000–50,000, affecting more than 5,000 individuals living in the United States and more than 20,000 in Europe. Our team consists of recognized global leaders in the field of DNA-targeted small molecules, transcription modulation, medicinal chemistry, translation, and development into clinical applications. "We have reached the point where AI finally allows us to see biology in new ways, and translate those discoveries to better treatments for disease," said Robert Nelsen, Managing Director and Co-Founder of ARCH Venture Partners. "This creates an enormous opportunity for us to rethink drug discovery entirely. For this reason, Xaira is the largest initial funding commitment in ARCH history."

Deepa Prasad serves as an independent advisor to Équilibre Biopharmaceuticals Corp. and Graviton Biosciences. Prior to vTv, Ms. Prasad was managing director at WestRiver Group, where she led investments in healthcare innovation across biotech and digital health/AI. Ms. Prasad has held various healthcare operational roles as chief of staff at Blue Shield of California, regional vice president for Optum, head of managed care at the California Hospital Association, and vice president, financial strategy and business development at Coherus Biosciences (CHRS). She began her career in investment banking working with biotech and pharma companies on private placements and buyside and sellside mergers and acquisitions, including cross-border M&A with several Japanese pharma.

In addition to its lead GeneTAC™ small molecule, DT-216, in development for patients with Friedreich ataxia, the company is advancing programs in Fuchs endothelial corneal dystrophy, Huntington’s disease and myotonic dystrophy type-1. We are developing a portfolio of GeneTAC™ product candidates designed to address genetic diseases driven by inherited nucleotide repeat expansions. GeneTAC™ molecules are designed to be a novel class of disease-modifying small molecule therapeutic candidates that can either dial up or dial down the expression of a specific disease-causing gene to address the underlying cause of disease. The development of drugs to treat genetic disease has largely focused on novel complex modalities such as gene therapy or gene editing that have proven to be challenging to develop. Until recently, scientists had not succeeded in using small molecules for selective, targeted transcription modulation. Through our GeneTAC™ platform, we have designed small molecules that effectively target and dial up or down the expression of specific genes, with one of our lead compounds having entered the clinic in 2022.

As an exploratory objective, the company also evaluated FXN expression including levels of FXN mRNA and protein in skeletal muscle biopsies obtained at pre-dose baseline and two and seven days after the third weekly dose. In the hands of an experienced team of drug developers, Xaira’s platform forms the basis of a robust therapeutic product development capability across multiple modalities. Its design capabilities, applied to previously difficult to drug targets, are the foundation for a pipeline of differentiated therapeutics.

You Can Now Golf at Tiger Woodss Las Vegas PopStroke Experience

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Notably, you can look forward to exceptional steaks, large side dishes suitable for sharing, and a vast scotch menu. The Steakhouse at Circus Circus is an iconic dining location in Las Vegas. Known for serving top-quality Midwestern beef, this restaurant has been a part of the city’s dining scene for over 30 years. Bavette’s Steakhouse & Bar is a renowned dining destination known for its classic steakhouse fare with a twist. You’ll find this gem situated within the glamorous confines of the Park MGM in Las Vegas. On Monday, the Las Vegas Review-Journal published a story saying that country music star Morgan Wallen may be opening a country music restaurant on the Las Vegas Strip.

Oscar’s Steakhouse

This restaurant, located just a stone’s throw from the casino floor and Convention Center at Mandalay Bay, has been stylishly redesigned to create an inviting atmosphere. As a guest, you’ll find yourself surrounded by an ambiance that exudes old-time New York charm. Expect a menu that boasts of delectable steaks and seafood, providing a rich dining experience that caters to the discerning palate. At ONE, you can feast on steaks from Midwestern archers, such as bone-in filet mignon, ribeye, and Strauss veal chop. There are also a couple of Wagyu options (hailing from Japan and the U.S.), and fun surf-and-turf dishes, like a Wagyu strip and Alaskan king crab leg combo.

Private Events

On your way out, pick up corn-finished ribeye from the butcher side of the restaurant, so you can grill another steak (or three) for dinner back at home. T-Bones is the special occasion spot when you want to avoid the Strip and get the highest-quality meats in the suburbs. It’s best to grab a seat at the onyx marble bar so you can eavesdrop on weekend golf plans and chat up the bartender about the latest neighborhood scandal. The kobe beef is excellent, the kind of steak so tender that it’s like cutting through Jell-O to reveal a perfectly-marble inside. Post up with some fondue mac and cheese or creamed spinach and count how many couples are celebrating their anniversary. After devouring the appetising menu with your eyes, you’ll be ready to feast upon the tantalising dishes on offer.

Eater Vegas main menu

The good news is that you get a 50% discount on steaks during happy hour, so dig in. Choose from items like a New York strip, a flat iron steak, a bone-in pork chop, or a ribeye. The menu also features mains such as pan-roasted dover sole and sides like king crab and artichoke gratin.

William B's Steakhouse is now open at the Suncoast Hotel and Casino - KTNV 13 Action News Las Vegas

William B's Steakhouse is now open at the Suncoast Hotel and Casino.

Posted: Thu, 09 Nov 2023 08:00:00 GMT [source]

Located inside the Park MGM, Bavette's boasts a gorgeous, sexy setting, outfitted with red leather banquettes, low lighting, and a blue-tiled bar. The stylish atmosphere translates into the menu, as well, starting out with the potent cocktails — there is a variety of martinis and Old Fashioneds, as well as classics like a Sazerac and Gimlet. Brown spirit lovers will be delighted with the ample selection of bourbon, whiskey, and scotch. Our selection includes joints developed by top chefs who've set up shop in some of the best hotels in town, like Jean Georges Vongerichten and Emeril Lagasse, with their expected quality in food and service. But there's plenty to explore beyond the Strip, including a couple of old-school jewels, and even a spot that is better known for its excellent drinks. But this being Vegas, you can be sure there's something here that your carnivorous spirit will be excited to devour.

This sleek spot at the Sahara manages to be creative without sacrificing quality, which can be difficult in a city that loves dupes of World Wonders. The menu kicks off with appetizers like pan-seared foie gras, beef carpaccio, and Creole boiled shrimp cocktail, and, yes, there is gumbo in the soup section. When it's time for steak, all meat marvels like a boneless New York strip, chateaubriand, and filet mignon all come from Creekstone Farms. You will also find Japanese Wagyu, Kurobuta pork chops, and New Zealand king salmon. The Wynn is home to this American steakhouse, awarded with Four Stars by the Forbes Travel Guide.

Barry’s Downtown Prime

steak house las vegas

And at the end of this year, we’ll be gaining another serious contender with the expansion of Peter Luger’s iconic New York steakhouse. In the meantime though, if you need help separating the good from the great, check out these top picks for the best steakhouses in Las Vegas. Meat lovers will enjoy options like an extra-thick New York called the Longhorn, a 24-ounce Porterhouse, or double-cut lamb chops served with mint jelly. Any of these can be served with the house butter (with garlic, lemon, and herbs), or Oscar-style, with a topping of crabmeat, asparagus, and hollandaise sauce. At Strip House Steakhouse, you’ll be surrounded by walls adorned with photos of old-Hollywood stars as you enjoy prime cuts of steak charred to perfection. Alongside its steaks, the restaurant also boasts a raw bar, adding to the variety of options available to satisfy your cravings.

Where to Find Passover Food in Las Vegas, 2024

Forget about steaks for a moment and go for the fantastic Angus Burger at Oscar’s. It’s a juicy piece of meat between two slices of toasted brioche with american cheese, and doused in Plaza sauce, a creamy topping that’s like fancy In N’ Out spread. Yes, it’s messy, but you won’t even think about putting it down for a second.

Delmonico Steakhouse is a high-end dining establishment owned by celebrity chef Emeril Lagasse. It’s situated in the heart of Las Vegas, inside the opulent Venetian Resort. I’ve ordered it three times now, the last time as a Christmas gift to my son, an avid cook. Glamorous meals at the big-name hotels, low-key dinners off the Strip, and more great options in Las Vegas.

Here are 12 casual, affordable restaurants for when you and your wallet need a break. Boozy party scenes, patios with killer views, and more of our favorite places in Vegas to start the day.

Vintage glamour and hospitality meet modern innovation and design at Barry’s Downtown Prime, the new steakhouse concept from Make It Happen Hospitality, LLC. Barry’s Downtown Prime will deliver the city’s finest steaks and seafood, fresh tableside preparations, creative cocktails, and outstanding service. StripSteak at Mandalay Bay in Las Vegas is a highly-rated steakhouse that combines modern American cuisine with a curated menu of seafood and signature cuts.

'Fuller House' Netflix Cast: Where Are They Now?

cast in fuller house

It was their last role together and Ashley's last major acting role to date, though she has popped up in bit parts in The Jerk Theory (2009) and I'm Still Here (2010). Fuller House is an American sitcom created by Jeff Franklin and produced by Warner Bros. Television Group that airs as a Netflix original series and is the sequel to the ABC television series Full House, which ran from 1987 to 1995.

cast in fuller house

Five Dates with Kimmy Gibbler

Becky moved to San Francisco to work alongside Danny as a cohost on Wake Up, San Francisco. Jesse began dating Becky and the two got married in season 4, after a few ups and downs with some of Jesse's exes. Once married, the couple moved into Becky's apartment.

Where is Luke Gulbranson from Summer House now?

Though his parents initially did not project show business aspirations onto their children, a family friend in the business noted to Barbara that ... John Phillip Stamos was born in Cypress, California, to Loretta (Phillips), a model, and William Stamos, a restaurateur. His father was of Greek descent, with the family surname originally being "Stamotopoulos". John has two younger sisters, Janeen and Alaina, both school teachers. In 2002, she married Jeremy Rytky, with whom she has two children; they divorced in 2014. Fuller House was her first role (with the exception of an appearance on It's F-----' Late with Dave Coulier) since the original series' end.

cast in fuller house

John Stamos

Stephanie Judith Tanner (portrayed by Jodie Sweetin) is the witty, sarcastic middle child of Danny and Pam, the younger sister of D.J., and the older sister of Michelle. Her catchphrases during the early seasons of the series include "how rude!," "well, pin a rose on your nose!", and "hot dog". She eventually evolved into something of a tomboy in seasons four and five. Stephanie has a habit of spying on D.J.'s life by reading her diary and eavesdropping on her telephone calls (having been caught in the act several times), and is generally the most athletic and nosiest of the Tanner girls. Steve tells Kimmy about D.J.'s confession and his intention to confront D.J.

They become a couple in the finale episode of season three but she breaks up with him in season four. Harry Takayama (portrayed by Nathan Nishiguchi in Full House; Michael Sun Lee in Fuller House) is the first on-screen friend of Stephanie's (appearing in season two, beginning with the episode "Middle Age Crazy"). He usually calls her "Chief", and she refers to him as her boyfriend—without understanding that term's full meaning (as Stephanie put it in Harry's first appearance, "you're a boy, and you're my friend; that makes you my boyfriend"). Stephanie decides to have a pretend wedding with Harry in "Middle Age Crazy," feeling that she is not receiving attention from the rest of the family. His last appearance is in the season three episode "Nerd For a Day".

Lindsay Hubbard to Carl Radke: “I Know I Want to Have Your Children”

But that's exactly what happened with Full House, which aired from 1987 to 1995. Alan Thicke played a guest role as Mike, Crystal's grandfather, in an episode from season two. The fifth and final season was split into two parts and was comprised of 18 episodes. None of them have done a sitcom before, which is remarkable,” Dave Coulier, who appears in 3 of the 13 episodes, tells PEOPLE. And the new kids are getting the same treatment that the old kids did in the Full House days. Acted as a maternal figure to her younger sisters, like when she took care of Michelle when Jesse, Joey, and Stephanie all had chicken pox.

'Full House's Tanner Family Tree Explained - Collider

'Full House's Tanner Family Tree Explained.

Posted: Tue, 19 Dec 2023 08:00:00 GMT [source]

In the season seven episode "The Apartment," it is revealed that she got married and pregnant at age 16. Kathy shows up to her 20th high school reunion in Fuller House. He goes on an eight-day vacation and when he comes back to work he tells D.J.

To cheer him up, the girls somehow tracked down Vicky and surprised him with her. He invites her to the 30th "Dadi-versary" party the girls threw for him, Jesse and Joey. Since Becky, Jesse and Joey are all moving back to San Francisco, Danny announces he's moving back too, and back into the house. In season four Becky's talk show The Gab was a success but it turned back into Wake Up San Francisco. Danny refused to audition to be her co-host, and briefly lived life as a retiree. He eventually realizes that he misses being on air and gets his old job back after Becky's co-host gets injured.

Family Business

'Full House' cast cries remembering Bob Saget 2 years after his death - USA TODAY

'Full House' cast cries remembering Bob Saget 2 years after his death.

Posted: Thu, 11 Jan 2024 08:00:00 GMT [source]

Tanner-Fuller gets help from her sister Stephanie and best friend Kimmy when the women move in with their families to help D.J. Rusty (portrayed by Jordan Christopher Michael) is the son of Cindy, Danny's girlfriend in season four, first appearing in "Terror in Tanner Town". Rusty has a penchant of performing mischievous antics and practical jokes that wreak havoc on the family. It is also revealed that Cindy and his father have broken up.

He was last seen in "Stephanie Plays the Field," training for baseball with Stephanie. Irene Katsopolis (portrayed by Rhoda Gemignani in "The Return of Grandma", Yvonne Wilder in later appearances) is Jesse and Pam's mother, the wife of Nick Katsopolis, and maternal grandmother to D.J., Stephanie, and Michelle. She often talked about diapering Jesse's "tushy", and touched his and other people's "tushies," which made Jesse mad; at other times, she would talk about when Jesse was a kid. She often mentioned how she is older than Nick, and her passion for younger men (which makes Nick feel inferior at times). Max Fuller (portrayed by Elias Harger) is D.J.'s well dressed and intelligent middle child. He likes science, and is shown to be a clean freak like his grandfather.

It is revealed that she works as a dry cleaner in that episode and she first met Danny when he comes to the store as a customer. Cindy also has a precocious and troublesome 10-year-old son named Rusty. In the series finale "Michelle Rides Again," Steve shows up at the Tanner house to take D.J.

Full House is an American sitcom that aired for eight seasons on ABC, premiering Sept. 22, 1987 and ending May 23, 1995. Though the show never garnered much critical acclaim, it was a hit with audiences and even more so in syndicated reruns. From Uncle Jesse to Michelle Tanner, these are the characters everyone fell in love with in the '90s. Here's what's going on with the cast that played them all these years later. The siblings appeared on two episodes of "Fuller House." Steve spent a lot of time at his girlfriend D.J.'s house and he was always eating something from their fridge.

In the same interview, Barber reveled she has really enjoyed being a stay-at-home mom, living the childhood she never had. Although the twins first launched a clothing line at Walmart, their follow-up was much more high end, founding brands The Row in 2006, and Elizabeth & James in 2007. They've had such a big impact on the fashion world that in both 2012 and 2015, the sisters were named Womenswear Designers of The Year by The Council of Fashion Designers of America. In 2014, they were named Accessory Designers of the Year. In 2007, the boho-chic duo launched Elizabeth & James, a contemporary collection inspired by their personal tastes. Furthermore, they've released a line called Olsenboye for J.C.

However, as they grew older, their fighting dissipated and they learned to comfort one another in the moments they missed their mother the most. The theme song "Everywhere You Look" by Jesse Frederick went through various instrumental versions in the closing credits. When ABC Family acquired the show in 2003, it was the first television network to play a longer version of the theme song (for seasons 1 through 5) since the show's initial run on ABC had featured it in just a handful of episodes. In between, Kimmy Gibbler got married to Spanish car racer, Fernando, and the two have a daughter together, Ramona. Unfortunately, Fernando wasn't a loyal husband and Kimmy has caught him cheating on her multiple times, prompting her to divorce him. However, despite the multiple infidelities, Kimmy still has feelings for Fernando and he tries hard to win back Kimmy's feelings.

She is an actress and producer, known for Summerland (2004), When Calls the Heart (2014) and Full House (1987). She has been married to Mossimo Giannulli since November 27, 1997. Since Full House, Loughlin's pretty much been a staple on TV screens everywhere. She's starred in shows like In Case of Emergency, 90210, What Calls the Heart and Summerland, which she co-created and produced, not to mention her numerous Hallmark Channel movies and holiday films. Pamela (portrayed by Madilynn Jefferson and McKenzie Jefferson) is the adoptive daughter of Jesse and Becky.

She led Fuller House through all five seasons and has appeared in numerous TV movies and on reality shows since. Throughout the series, he fronted a band named Jesse and the Rippers and was the lead vocalist and guitarist. The band scored a record deal after the success of their hit single "Forever" (a Beach Boys cover). They then toured the country in local clubs during the summer.

Uber, Lyft drivers to rally at Rhode Island State House

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